Jiahuai Han: Aflame on inflammation and p38

Specific Regulation of Noncanonical p38 Activation by Hsp90-Cdc37 Chaperone Complex in Cardiomyocyte

Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice

Objective(s): The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl4)-induced liver toxicity. Materials and Methods: Hepatotoxicity was induced in mice by a single subcutaneous injection (SC) of CCl4. The LCB was administered orally once a day for seven days (PO) as pretreatment at three doses of 1, 5, and...

The role of the p38 pathway in adaptive immunity.

Since its discovery in 1993, the mitogen-activated protein (MAP) kinase p38 has attracted much attention for its role in a wide range of cellular processes, many of which involve the immune system. Although p38 has been heavily implicated in the function of all type immune cells, research has tended focus on its role in innate immunity. In this review we attempt to highlight some of the major d...

IL-6 activates serum and glucocorticoid kinase via p38 mitogen-activated protein kinase pathway

mitogen-activated protein kinase pathway α IL-6 activates serum and glucocorticoid kinase via p38 You might find this additional info useful... molecular physiology. It is published 12 times a year (monthly) by the American Physiological Society, 9650 is dedicated to innovative approaches to the study of cell and

p38 and a p38-Interacting Protein Are Critical for Downregulation of E-Cadherin during Mouse Gastrulation

During vertebrate gastrulation, an epithelial to mesenchymal transition (EMT) is necessary for migration of mesoderm from the primitive streak. We demonstrate that p38 MAP kinase and a p38-interacting protein (p38IP) are critically required for downregulation of E-cadherin during gastrulation. In an ENU-mutagenesis screen we identified the droopy eye (drey) mutation, which affects splicing of p...